Bioengineering of Mesenchymal Stromal Cells for Regenerative Medicine

Grant Project Details:

Awardee:
Elizabeth Siegler, PhD
Timeframe:
2021-2023
Location:
Mayo Clinic | Rochester , MN
Amount:
$250,000
Status:
In Process
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Grant Location

Mayo Clinic
Rochester , MN 55905

Grant Description

Mesenchymal stromal cells (MSCs) have intrinsic immunosuppressive and regenerative properties. We seek to engineer MSCs with artificial receptors to enhance these properties and improve therapeutic efficacy for the treatment of autoimmune disease. We will use mouse models of colitis to test the benefits of these engineered MSCs over unmodified MSCs. We aim to broaden treatment options for patients living with ulcerative colitis, Crohn's disease, and other autoimmune disorders.

Grant Awardee Biography

Dr. Siegler