A multi-omics approach for the identification of species-specific developmental states and speed during interspecies chimerism

1. Construct integrative models that characterize the developmental states and rhythms of early embryogenesis.
2. Identify the developmental differences in host and donor cells in chimeric embryos of evolutionary close and distant species.
3. Identify key regulators of the developmental timing of host and donor cells in chimeric embryos.
4. Our long-term goal is to establish the basis for a better generation of human organs in host animals through interspecies chimerism.