Development Of Novel Proteolytic Targeting Chimeras That Promote Cartilage Regeneration

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of doctor visits, chronic disability, and joint pain. OA occurs when articular cartilage, a shock absorbing tissue between bones, degenerates because of injury, inflammation, or aging. No medications are available to regenerate cartilage or prevent its degradation. The goal of this project is to develop and test a new class of molecules that hold the potential to increase cartilage regeneration without affecting other tissues.